All figures provided by Min-Yeh Tsai

We live in a world of “molecules“. How do matter and molecules become living things? It’s the DNA molecule that shapes the mysteries of life. Using both theory and computational methods, we carries out complex bio-molecular simulation tasks in order to answer this question from a mechanistic point of view.

我們處在一個“分子”的世界。究竟物質/分子是如何轉變成生命？正是DNA分子塑造了生命的奧秘。本實驗室使用理論及計算方法來執行複雜的生物分子模擬，以便從分子機理的角度回答這個問題。

Our Mission

We use molecular dynamics simulations along with statistical mechanical approaches and kinetic modeling to study protein-protein/protein-DNA interactions. Specifically, we construct mechanistic pictures from very complex simulations and use the mechanism to develop predictive kinetic models for biochemical problems concerning the following:

1. Termolecular biophysics and biochemistry

2. Disease-related biomolecular condensates/aggregates

3. Protein-DNA structure-dynamics-function relationships.

The long-term goal of MYTLab research is aimed to understand how various biological specificities influence a cell's function at the molecular level.

我們的任務

我們使用分子動力學模擬以及統計力學方法、動力學建模來研究蛋白質-蛋白質/蛋白質-DNA 相互作用。 具體來說，我們從非常複雜的模擬中構建機制圖像，並使用該機制為涉及以下方面的生化問題開發預測性之動力學模型：

1. 分子生物物理與生物化學

2. 與疾病相關的生物分子凝聚物/聚集體

3. 蛋白質-DNA 結構-動態-功能之間的關係。

MYTLab 研究的長期目標是了解各種生物特異性如何在分子水平上影響細胞的功能。

What We've Achieved