We explore molecular life science through theory, curiosity, and enthusiasm.

我們透過理論、好奇心以及熱忱來探索分子生命科學。

Research in MYTLab is primarily at the interface of physics, chemistry, and biology. We employ physical and chemical theories to understand biological processes from a molecular perspective. Our research focuses on computational studies on protein-protein/protein-nucleic acids interactions using multi-scale molecular dynamics (MD) simulations (e.g., all-atom and coarse-graining approach). We aim to understand how biological specificity influences a cell’s function at the molecular level. Find out how you can contribute.

MYTLab 的研究主要是屬於物理、化學和生物學的交叉領域。 我們運用物理和化學理論從分子角度理解生物過程。 我們的研究重點是使用多尺度分子動力學模擬(例如,全原子和粗粒化方法)對蛋白質-蛋白質/蛋白質-核酸相互作用進行計算研究。 我們的目標是了解生物特異性如何在分子水平上影響細胞的功能。 了解您可以如何做出貢獻。

 

Our research is in the field of computational biophysics. We combine both theory and simulation to study the sequence-structure-function relationships in disease-related bio-molecular processes and gene regulation. In particular, we try to understand molecular mechanisms in terms of three key elements of physical chemistry: stability, structure, and kinetics.

我們的研究屬於【計算生物物理學】領域。 我們結合【理論】和【模擬】來研究與疾病相關的生物分子過程和基因調控的【序列-結構-功能】關係。我們試圖從物理化學的三個關鍵要素來理解分子機制: 穩定性、結構和動力學。

 
 

Min-Yeh Tsai

Head of MYTLab

 

CURRENT (2023.2-)

Assistant Professor at National Chung Cheng University (CCU)

 

Assistant PROFESSOR (2018.8-2023.1)

Tamkang University (TKU)

TKU_location.png
 

postdoc (2014-2018)

Rice University

with Prof. Peter Wolynes (member of National Academy of Sciences, USA)

 

R&D Fellow, ALTERNATIVE MILITARY DUTY (2011-2014)

National Yang Ming Chiao Tung University (NYCU)

with Prof. Sheng Hsien Lin

 

phd (2006-2011)

in Physical chemistry

National Taiwan University

with Prof. Sheng Hsien Lin (Academician of Academia Sinica, Taiwan)

 

bs (2001-2005)

in Chemistry

National Taiwan Normal University

 

Welcome to National Chung Cheng University (CCU)! Our university is nestled in the charming suburb of Minhsiung, Chiayi County. With the majestic Alishan Mountain as our backdrop, CCU enjoys a breathtaking setting encompassing verdant plains and sweeping ocean views.

At CCU, our name "Chung Cheng" embodies the essence of our institution's core values. It represents our unwavering dedication to continuously pursuing righteous actions. We firmly believe in the power of making choices that contribute to the betterment of society.

Located in such a serene and inspiring environment, CCU provides an ideal setting for academic and personal growth. Our university community is dedicated to fostering an atmosphere of learning, innovation, and ethical development.

Explore the opportunities that await you at National Chung Cheng University and embark on a transformative journey where knowledge, integrity, and righteousness converge. Join us in shaping a brighter future.

 

TamKang Univ. (TKU) is located in a beautiful harbor district, Tamsui. Situated at the foot of the Tatuen Mountain Range, TKU embraces the magnificent Tamsui River while lean against the emerald green Five Tiger Hill. Tamsui is enriched with famous ancient historical sites (Fort San Domingo build in 1628 by Spanish people, renovated in 1644 by Dutch people; Oxford College in 1882 sponsored by Canadian Presbyterian Missionary Dr. Mackay). Tamsui is a very walkable town for tourists to enjoy gourmet and old western buildings (Tamsui Old Street), and beautiful scenery (Tamsui Fisherman’s Wharf).

Highlights

 
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We carry out computational tasks, combine with analytical theory and use structural insight to solve important biochemical problems.
— MYTLab
We are able to construct mechanistic pictures from very complex simulations and use the mechanism to develop predictive kinetic models.
— MYTLab
 
This movie illustrates how protein monomers are positioned and initialized in the simulation box and how protein aggregates form from individual monomers bumping into each other randomly. (Courtesy of W. Zheng)

This movie illustrates how protein monomers are positioned and initialized in the simulation box and how protein aggregates form from individual monomers bumping into each other randomly. (Courtesy of W. Zheng)

Once Abeta peptides get misfolded initially (with appreciable hairpin-like conformations), they tend to form a small-size, meta-stable oligomer (ex. dimer), with their beta-sheet structure in anti-parallel. Under this circumstance, a fibril-like str…

Once Abeta peptides get misfolded initially (with appreciable hairpin-like conformations), they tend to form a small-size, meta-stable oligomer (ex. dimer), with their beta-sheet structure in anti-parallel. Under this circumstance, a fibril-like structure would NOT form until it undergoes the anti-parallel to parallel conformational conversion, called “backtracking“. As the size of this oligomer increases to a critical size (here dimer), the backtracking is not required; instead, the “Dock-and-lock“ mechanism would take place hereafter.

A short piece of DNA (100 bp) is under torque on the both ends whiling being horizontally pulled along the x-axis. (Courtesy of Xun Chen)

A short piece of DNA (100 bp) is under torque on the both ends whiling being horizontally pulled along the x-axis. (Courtesy of Xun Chen)

Molecular Dynamics simulation allows us to use “first-principle“ to track internal motions of biomolecules at desired resolution.